ALNYLAM PHARMACEUTICALS, INC.

Annual Trend FY 2016 FY 2017 FY 2018 FY 2019 FY 2020 FY 2021 FY 2022 FY 2023 FY 2024 FY 2025
Cash flows from operating activities:
Adjustments to reconcile net income to net cash provided by operating activities:
Net Income (Loss) Attributable to Parent ($410.1m) ($490.9m) ($761.5m) ($886.1m) ($858.3m) ($852.8m) ($1.1b) ($440.2m) ($278.2m) $313.7m
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest ($761.5m) ($886.1m) ($858.3m) ($852.8m) ($1.1b)
Depreciation, Depletion and Amortization $15.1m $13.4m $6.4m $17.2m $34.8m $47.6m $44.5m $54.1m $56.7m $55.7m
Depreciation $9.6m $11.9m $12.8m $16.6m $30.2m $36.8m $39.1m $51.6m $55.1m $54.8m
Deferred Income Tax Expense (Benefit) ($788k) ($2.0m) ($3.2m) ($2.8m) ($1.4m) ($713k) ($106.8m) ($2.2m)
Share-based Payment Arrangement, Noncash Expense $75.5m $92.8m $157.8m $174.8m $139.9m $165.7m $230.6m $221.7m $272.1m $348.2m
Payment, Tax Withholding, Share-based Payment Arrangement $596k $257k $3.5m
Share-based Payment Arrangement, Expense $174.8m $139.9m $165.7m $230.6m $221.7m $272.1m $348.2m
Gain (Loss) on Extinguishment of Debt ($76.6m) $0 $0 ($42.5m)
Income Tax Expense (Benefit) $823k $863k $2.7m $680k $4.2m $6.7m ($99.2m) $9.4m
Interest Expense Nonoperating $141.9m $252.6m
Operating Lease, Expense $50.7m $59.5m $58.6m $61.6m
Other Nonoperating Income (Expense) $6.2m ($3.0m) $4.2m $11.3m $45.5m ($2.0m) ($109.4m) ($125.7m) ($180.6m) $5.2m
Changes in operating assets and liabilities:
Additional Financial Items
Increase (Decrease) in Accounts Receivable ($15.2m) $24.2m $56.2m $101.8m $45.6m $87.9m $86.5m $360.0m
Increase (Decrease) in Inventories $22.6m $32.4m $35.4m $26.4m $34.1m ($18.4m) ($13.6m) ($8.5m)
Increase (Decrease) in Accounts Payable $10.1m ($4.9m) $15.5m
Debt Securities, Available-for-sale, Realized Gain (Loss) ($7.0m) $1.9m $0 ($11.3m) ($54.0m) ($55.7m) $33.3m $16.9m $3.0m $2.3m
Equity Securities, FV-NI, Gain (Loss) ($7.0m) $1.9m $3.6m $11.3m $54.0m $55.7m ($33.3m) ($16.9m) ($3.0m) ($2.3m)
Gain (Loss) Related to Litigation Settlement $20.6m $0
General and Administrative Expense $89.4m $199.4m
Induced Conversion of Convertible Debt Expense $42.5m
Investment Income, Interest $11.8m $1.6m $95.6m $122.0m $111.5m
Nonoperating Income (Expense) $14.5m $9.2m $54.0m $54.2m ($27.2m) ($143.5m) ($341.9m) ($151.3m) ($200.5m) ($178.4m)
Operating Expenses $471.7m $590.0m
Net Cash Provided by (Used in) Operating Activities ($307.7m) ($382.8m) ($562.6m) ($278.4m) ($615.0m) ($641.7m) ($541.3m) $104.2m ($8.3m) $524.1m
Cash flows from investing activities:
Payments to Acquire Property, Plant, and Equipment $64.6m $104.2m $126.9m $140.2m $70.4m $76.4m $72.1m $62.2m $34.3m $58.7m
Payments for (Proceeds from) Other Investing Activities $7.0m $5.3m $4.2m $4.7m $4.4m $117k $2.1m
Net Cash Provided by (Used in) Investing Activities $142.6m ($290.4m) $272.9m ($417.7m) ($435.5m) ($273.3m) $169.4m ($336.4m) ($116.8m) $436.3m
Cash flows from financing activities:
Proceeds from Issuance of Common Stock $1.1b $381.9m $0 $0
Net Cash Provided by (Used in) Financing Activities $177.8m $1.1b $65.5m $823.2m $995.0m $1.2b $425.8m $172.1m $294.2m ($305.2m)
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents $0 $0 ($83k) $4.9m ($9.0m) ($7.4m) $6.4m ($15.2m) $34.9m
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect $0 ($224.2m) $127.0m ($50.6m) $323.1m $46.4m ($53.7m) $153.8m $690.2m
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents $0 $0 ($83k) $4.9m ($9.0m) ($7.4m) $814.9m $968.7m $1.7b
Supplemental disclosure of cash flow information:
Interest Paid, Excluding Capitalized Interest, Operating Activities $1.1m $2.4m $775k $172k $0 $24.7m $45.2m $32.1m $67.6m $218.7m
Income Taxes Paid, Net $111k $14.4m $15.1m

Values abbreviated: b = billions, m = millions, k = thousands. Per share data in USD.