|
Cash flows from operating activities:
|
|
|
|
|
|
|
|
|
|
|
|
|
Adjustments to reconcile net income to net cash provided by operating activities:
|
|
|
|
|
|
|
|
|
|
|
|
|
Net Income From Continuing Operations
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$183.4m
|
$14.1m
|
($43.2m)
|
$59.0m
|
|
Net Income (Loss) Attributable to Parent
|
|
($1.5m)
|
($64.9m)
|
($103.2m)
|
($161.9m)
|
($161.4m)
|
($157.9m)
|
$183.4m
|
$14.1m
|
($43.2m)
|
$59.0m
|
|
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
|
|
—
|
($64.9m)
|
($103.2m)
|
($161.9m)
|
($161.4m)
|
($157.9m)
|
$183.4m
|
$14.1m
|
($43.2m)
|
$59.0m
|
|
Depreciation and amortization
|
|
—
|
—
|
—
|
—
|
—
|
$2.4m
|
$2.4m
|
$2.3m
|
$1.7m
|
$1.6m
|
|
Depreciation
|
|
—
|
$28k
|
$286k
|
$2.1m
|
$2.4m
|
$1.5m
|
$1.2m
|
$1.1m
|
$448k
|
$196k
|
|
Depreciation and amortization expense
|
|
—
|
—
|
—
|
$2.1m
|
$2.4m
|
$2.4m
|
$2.4m
|
$2.3m
|
$1.7m
|
$1.6m
|
|
Net amortization (accretion) of discounts on short-term investments
|
|
—
|
—
|
($1.4m)
|
($3.5m)
|
$123k
|
$664k
|
($82k)
|
($1.1m)
|
$441k
|
($916k)
|
|
Amortization Of Securities
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($82k)
|
($1.1m)
|
$441k
|
($916k)
|
|
Depreciation Amortization Depletion
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$2.4m
|
$2.3m
|
$1.7m
|
$1.6m
|
|
Deferred Income Tax Expense (Benefit)
|
|
—
|
($197k)
|
($978k)
|
($3.2m)
|
$4.4m
|
$11k
|
($185.5m)
|
($33.8m)
|
$8.1m
|
$13.0m
|
|
Deferred income taxes
|
|
—
|
($197k)
|
($978k)
|
($3.2m)
|
$4.4m
|
$11k
|
($185.5m)
|
($33.8m)
|
$8.1m
|
$13.0m
|
|
Deferred Income Tax
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($185.5m)
|
($33.8m)
|
$8.1m
|
$13.0m
|
|
Deferred Tax
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($185.5m)
|
($33.8m)
|
$8.1m
|
$13.0m
|
|
Share-based Payment Arrangement, Noncash Expense
|
|
—
|
$897k
|
$5.7m
|
$15.1m
|
$20.9m
|
$25.2m
|
$25.1m
|
$27.1m
|
$30.7m
|
$37.0m
|
|
Payment, Tax Withholding, Share-based Payment Arrangement
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$901k
|
$2.2m
|
$5.0m
|
$7.7m
|
|
Share-based Payment Arrangement, Expense
|
|
—
|
$897k
|
$5.7m
|
$15.1m
|
$20.9m
|
$25.2m
|
$25.1m
|
$27.1m
|
$30.7m
|
$37.0m
|
|
Share-based compensation expense
|
|
$0
|
$897k
|
$5.7m
|
$15.1m
|
$20.9m
|
$25.2m
|
$25.1m
|
$27.1m
|
$30.7m
|
$37.0m
|
|
Gain (Loss) on Disposition of Property Plant Equipment
|
|
—
|
—
|
($66k)
|
($21k)
|
—
|
($103k)
|
($33k)
|
($179k)
|
($1k)
|
$120k
|
|
Income Tax Expense (Benefit)
|
|
—
|
$2k
|
($214k)
|
($2.0m)
|
$5.2m
|
$1.4m
|
($172.3m)
|
($30.7m)
|
$7.0m
|
$29.9m
|
|
Operating lease liabilities
|
|
—
|
—
|
—
|
($1.3m)
|
($1.7m)
|
($2.6m)
|
($3.0m)
|
($3.3m)
|
($4.0m)
|
($3.5m)
|
|
Changes in operating assets and liabilities:
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional Financial Items
|
|
|
|
|
|
|
|
|
|
|
|
|
Increase (Decrease) in Accounts Receivable
|
|
—
|
—
|
—
|
—
|
—
|
$3.9m
|
$8.7m
|
$8.6m
|
$20.5m
|
($26.1m)
|
|
Increase (Decrease) in Inventories
|
|
—
|
—
|
—
|
—
|
—
|
$3.7m
|
$17.9m
|
$9.5m
|
($4.8m)
|
$28.5m
|
|
Increase (Decrease) in Accounts Payable
|
|
—
|
$1.0m
|
$8.8m
|
($4.7m)
|
($5.0m)
|
$1.4m
|
$6.0m
|
$347k
|
($6.3m)
|
$142k
|
|
Proceeds from Stock Options Exercised
|
|
—
|
—
|
$377k
|
$1.1m
|
$6.6m
|
$5.3m
|
$2.6m
|
$2.9m
|
—
|
—
|
|
Debt Securities, Available-for-sale, Realized Gain (Loss)
|
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
$0
|
$0
|
|
General and Administrative Expense
|
|
—
|
$9.0m
|
$21.6m
|
$35.0m
|
$45.3m
|
—
|
—
|
—
|
—
|
—
|
|
Investment Income, Interest
|
|
—
|
$529k
|
$4.7m
|
$6.0m
|
$1.1m
|
$97k
|
—
|
—
|
$9.0m
|
$11.6m
|
|
Operating Expenses
|
|
—
|
$65.4m
|
$108.2m
|
$170.0m
|
$157.4m
|
—
|
—
|
—
|
—
|
—
|
|
Non-cash lease expense
|
|
—
|
—
|
—
|
$1.2m
|
$1.4m
|
$2.6m
|
$3.0m
|
$3.1m
|
$3.1m
|
$3.7m
|
|
Prepaid expenses and other current assets
|
|
($4k)
|
($1.2m)
|
($4.8m)
|
($1.0m)
|
($1.3m)
|
$2.9m
|
($3.9m)
|
($7.1m)
|
($2.7m)
|
($22.5m)
|
|
Accounts receivable, net
|
|
—
|
—
|
—
|
—
|
—
|
($3.9m)
|
($8.7m)
|
($8.6m)
|
($20.5m)
|
$26.1m
|
|
Inventory
|
|
—
|
—
|
—
|
—
|
—
|
($3.7m)
|
($17.9m)
|
($9.5m)
|
$4.8m
|
($28.5m)
|
|
Contract asset
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($7.7m)
|
$7.7m
|
—
|
—
|
|
Other long-term assets
|
|
—
|
—
|
—
|
—
|
($5.6m)
|
($3.3m)
|
$2.7m
|
$4.6m
|
($9.7m)
|
($1.2m)
|
|
Accounts payable
|
|
$277k
|
$1.0m
|
$8.8m
|
($4.7m)
|
($5.0m)
|
$1.4m
|
$6.0m
|
$347k
|
($6.3m)
|
$142k
|
|
Accrued expenses, accrued collaboration expenses and other current liabilities
|
|
—
|
$4.1m
|
$9.3m
|
$4.6m
|
$8.8m
|
$10.3m
|
($3.7m)
|
$16.9m
|
$43.7m
|
$37.5m
|
|
Deferred revenue
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$12.0m
|
$261k
|
$19.6m
|
—
|
|
Other long-term liabilities
|
|
—
|
—
|
—
|
$326k
|
$478k
|
($535k)
|
$1.6m
|
$19k
|
($35k)
|
$16.7m
|
|
Proceeds from issuance of Class A ordinary shares under incentive award plans and employee share purchase plan
|
|
—
|
—
|
—
|
$1.1m
|
$6.6m
|
$5.9m
|
$3.4m
|
$3.7m
|
$17.2m
|
$40.8m
|
|
Payments in connection with ordinary stock tendered for employee tax obligations
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($901k)
|
($2.2m)
|
($5.0m)
|
($7.7m)
|
|
Change in right-of-use asset as a result of new, modified, and terminated leases
|
|
—
|
—
|
—
|
—
|
—
|
$1.6m
|
$2.9m
|
$9.6m
|
$1.6m
|
$3.1m
|
|
Additions to property and equipment included in accrued expenses and other liabilities
|
|
—
|
—
|
$1.3m
|
$222k
|
—
|
—
|
—
|
$54k
|
$153k
|
$83k
|
|
Beginning Cash Position
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$122.5m
|
$122.7m
|
$108.0m
|
$183.6m
|
|
Cash Flow From Continuing Financing Activities
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$2.5m
|
$1.5m
|
$12.3m
|
$33.0m
|
|
Cash Flow From Continuing Investing Activities
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($8.1m)
|
($29.6m)
|
$37.7m
|
($189.0m)
|
|
Change In Account Payable
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$6.0m
|
$347k
|
($6.3m)
|
$142k
|
|
Change In Accrued Expense
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($3.7m)
|
$16.9m
|
$43.7m
|
$37.5m
|
|
Change In Inventory
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($17.9m)
|
($9.5m)
|
$4.8m
|
($28.5m)
|
|
Change In Other Current Assets
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$2.7m
|
$4.6m
|
($9.7m)
|
($1.2m)
|
|
Change In Other Current Liabilities
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($1.4m)
|
($3.2m)
|
($4.0m)
|
$13.2m
|
|
Change In Other Working Capital
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$12.0m
|
$261k
|
$19.6m
|
—
|
|
Change In Payable
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$6.0m
|
$347k
|
($6.3m)
|
$142k
|
|
Change In Payables And Accrued Expense
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$2.3m
|
$17.3m
|
$37.4m
|
$37.6m
|
|
Change In Prepaid Assets
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($3.9m)
|
($7.1m)
|
($2.7m)
|
($22.5m)
|
|
Change In Receivables
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($16.3m)
|
($950k)
|
($20.5m)
|
$26.1m
|
|
Change In Working Capital
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($22.6m)
|
$1.4m
|
$24.8m
|
$24.8m
|
|
Changes In Account Receivables
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($8.7m)
|
($8.6m)
|
($20.5m)
|
$26.1m
|
|
Changes In Cash
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$245k
|
($14.8m)
|
$75.6m
|
($18.0m)
|
|
End Cash Position
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$122.7m
|
$108.0m
|
$183.6m
|
$165.6m
|
|
Financing Cash Flow
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$2.5m
|
$1.5m
|
$12.3m
|
$33.0m
|
|
Free Cash Flow
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$5.7m
|
$13.2m
|
$25.4m
|
$136.4m
|
|
Gain Loss On Sale Of PPE
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$33k
|
$179k
|
($24k)
|
($120k)
|
|
Investing Cash Flow
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($8.1m)
|
($29.6m)
|
$37.7m
|
($189.0m)
|
|
Issuance Of Capital Stock
|
|
—
|
—
|
—
|
—
|
—
|
$0
|
$3.4m
|
—
|
—
|
—
|
|
Net Intangibles Purchase And Sale
|
|
—
|
—
|
—
|
—
|
—
|
($20.0m)
|
$0
|
$0
|
—
|
—
|
|
Net PPE Purchase And Sale
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($14k)
|
($130k)
|
($252k)
|
($1.6m)
|
|
Operating Gains Losses
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$33k
|
$179k
|
($24k)
|
($120k)
|
|
Other Non Cash Items
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$3.0m
|
$3.1m
|
$3.1m
|
$3.7m
|
|
Proceeds From Stock Option Exercised
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$3.4m
|
$3.7m
|
$17.2m
|
$40.8m
|
|
Purchase Of Intangibles
|
|
—
|
—
|
—
|
—
|
—
|
($20.0m)
|
$0
|
$0
|
—
|
—
|
|
Purchase Of PPE
|
|
—
|
—
|
$5.3m
|
$3.2m
|
$283k
|
$415k
|
($105k)
|
($130k)
|
($277k)
|
($1.6m)
|
|
Repurchase Of Capital Stock
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($901k)
|
($2.2m)
|
($5.0m)
|
($7.7m)
|
|
Sale Of PPE
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$91k
|
$0
|
$25k
|
$0
|
|
Stock Based Compensation
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$25.1m
|
$27.1m
|
$30.7m
|
$37.0m
|
|
Net Cash Provided by (Used in) Operating Activities
|
|
($882k)
|
($50.2m)
|
($81.0m)
|
($158.4m)
|
($136.5m)
|
($126.3m)
|
$5.8m
|
$13.3m
|
$25.7m
|
$138.0m
|
|
Cash flows from investing activities:
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments to Acquire Property, Plant, and Equipment
|
|
—
|
$69k
|
$5.3m
|
$3.2m
|
$283k
|
$415k
|
$105k
|
$130k
|
$277k
|
$1.6m
|
|
Purchases of short-term investments
|
|
—
|
—
|
($402.0m)
|
($488.8m)
|
($430.2m)
|
($157.2m)
|
($135.9m)
|
($204.9m)
|
($202.0m)
|
($386.9m)
|
|
Net Investment Purchase And Sale
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($8.1m)
|
($29.4m)
|
$37.9m
|
($187.4m)
|
|
Purchase Of Investment
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($135.9m)
|
($204.9m)
|
($202.0m)
|
($386.9m)
|
|
Proceeds from the maturities of short-term investments
|
|
—
|
—
|
$168.1m
|
$541.2m
|
$407.1m
|
$306.3m
|
$127.8m
|
$175.5m
|
$239.9m
|
$199.5m
|
|
Sale Of Investment
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$127.8m
|
$175.5m
|
$239.9m
|
$199.5m
|
|
Net Cash Provided by (Used in) Investing Activities
|
|
$168k
|
($69k)
|
($239.2m)
|
$49.2m
|
($23.4m)
|
$128.6m
|
($8.1m)
|
($29.6m)
|
$37.7m
|
($189.0m)
|
|
Cash flows from financing activities:
|
|
|
|
|
|
|
|
|
|
|
|
|
Common Stock Issuance
|
|
—
|
—
|
—
|
—
|
—
|
$0
|
$3.4m
|
—
|
—
|
—
|
|
Net Common Stock Issuance
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($901k)
|
($2.2m)
|
($5.0m)
|
($7.7m)
|
|
Payments of Ordinary Dividends, Common Stock
|
|
—
|
$0
|
$0
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
|
Common Stock Payments
|
|
—
|
—
|
—
|
—
|
—
|
—
|
($901k)
|
($2.2m)
|
($5.0m)
|
($7.7m)
|
|
Net Cash Provided by (Used in) Financing Activities
|
|
$730k
|
$39.9m
|
$346.7m
|
$84.1m
|
$227.1m
|
$5.9m
|
$2.5m
|
$1.5m
|
$12.3m
|
$33.0m
|
|
Net increase (decrease) in cash and cash equivalents
|
|
—
|
($10.4m)
|
$26.5m
|
($25.0m)
|
$67.1m
|
$8.2m
|
$245k
|
($14.8m)
|
$75.6m
|
($18.0m)
|
|
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
|
|
—
|
$45.7m
|
$72.2m
|
$47.1m
|
$114.2m
|
$122.5m
|
$122.7m
|
$108.0m
|
$183.6m
|
$165.6m
|
|
Cash, Cash Equivalents, and Short-term Investments
|
|
—
|
—
|
$307.3m
|
$233.4m
|
$323.5m
|
$182.2m
|
$190.6m
|
$206.4m
|
$243.6m
|
$414.1m
|
|
Cash and cash equivalents at beginning of period
|
|
—
|
$45.7m
|
$72.2m
|
$47.1m
|
$114.2m
|
$122.5m
|
$122.7m
|
$108.0m
|
$183.6m
|
$165.6m
|
|
Supplemental disclosure of cash flow information:
|
|
|
|
|
|
|
|
|
|
|
|
|
Change In Cash Supplemental As Reported
|
|
—
|
—
|
—
|
—
|
—
|
—
|
$245k
|
($14.8m)
|
$75.6m
|
($18.0m)
|
|
Income Taxes Paid, Net
|
|
—
|
$290k
|
$383k
|
$1.7m
|
$482k
|
$1.3m
|
$10.7m
|
$5.6m
|
$2.0m
|
$3.0m
|