|
Depreciation and amortization
|
|
$139k
|
$305k
|
$595k
|
$3.2m
|
$10.8m
|
$23.6m
|
$24.2m
|
|
Amortization of debt discount and offering costs
|
|
—
|
—
|
$0
|
$0
|
$1.1m
|
$1.7m
|
$1.7m
|
|
Non-cash interest expense related to the revenue interest liability
|
|
$0
|
$335k
|
$17.6m
|
$16.0m
|
$5.1m
|
$0
|
$0
|
|
Operating lease liabilities
|
|
($51k)
|
($385k)
|
($649k)
|
($711k)
|
($940k)
|
($782k)
|
($1.9m)
|
|
Operating cash flows paid for operating lease
|
|
$170k
|
$576k
|
$864k
|
$911k
|
$1.1m
|
$1.3m
|
$2.6m
|
|
Net loss
|
|
($52.6m)
|
($103.3m)
|
($84.0m)
|
($135.7m)
|
($163.4m)
|
($87.9m)
|
($23.4m)
|
|
Stock-based compensation
|
|
$6.1m
|
$12.6m
|
$23.1m
|
$27.0m
|
$35.0m
|
$48.4m
|
$71.4m
|
|
Inventory reserves and firm commitment losses
|
|
—
|
—
|
$0
|
$0
|
$9.3m
|
$2.6m
|
$2.9m
|
|
Loss from termination of revenue interest purchase agreement
|
|
—
|
—
|
$0
|
$0
|
$49.1m
|
$0
|
$0
|
|
Unrealized foreign exchange (gain) loss
|
|
—
|
—
|
$0
|
$0
|
$1.8m
|
($1.2m)
|
($1.7m)
|
|
Non-cash lease expense
|
|
—
|
—
|
$380k
|
$443k
|
$620k
|
$1.4m
|
$1.7m
|
|
Other
|
|
—
|
—
|
—
|
($3.5m)
|
($1.1m)
|
($795k)
|
($1.4m)
|
|
Accounts receivable
|
|
—
|
—
|
$0
|
($20.7m)
|
($44.0m)
|
($11.4m)
|
($48.1m)
|
|
Prepaid and other current assets
|
|
($2.7m)
|
($1.8m)
|
($4.0m)
|
($3.7m)
|
($3.6m)
|
($849k)
|
($5.8m)
|
|
Inventory
|
|
—
|
$0
|
($495k)
|
($3.4m)
|
($4.4m)
|
($3.2m)
|
($8.4m)
|
|
Other assets
|
|
($160k)
|
($954k)
|
($519k)
|
($127k)
|
($511k)
|
($1.5m)
|
($5.7m)
|
|
Accounts payable, accrued expenses and other liabilities
|
|
$10.1m
|
$3.7m
|
$22.7m
|
$7.6m
|
$30.8m
|
$40.3m
|
$50.1m
|
|
Purchase of property and equipment
|
|
($281k)
|
($225k)
|
($24k)
|
($278k)
|
($109k)
|
($993k)
|
($954k)
|
|
Cash paid for acquisition
|
|
—
|
—
|
$0
|
$0
|
($212.8m)
|
$0
|
$0
|
|
Payments made for additions to intangible assets
|
|
—
|
—
|
($19.0m)
|
$0
|
($20.0m)
|
($20.0m)
|
$0
|
|
Proceeds from issuance of convertible notes, net
|
|
—
|
—
|
$0
|
$0
|
$305.3m
|
$0
|
$0
|
|
Payments of deferred offering costs
|
|
$0
|
($158k)
|
$0
|
$0
|
($281k)
|
$0
|
$0
|
|
Payments on revenue interest liability
|
|
—
|
$0
|
($121k)
|
($5.6m)
|
($195.6m)
|
$0
|
$0
|
|
Accrued milestone payments classified as intangible assets, net
|
|
—
|
—
|
$0
|
$15.0m
|
$0
|
$0
|
$35.0m
|
|
Right-of-use assets obtained in exchange for lease liabilities
|
|
$3.7m
|
$0
|
$0
|
$285k
|
$473k
|
$9.6m
|
$2.4m
|
|
Decrease in ROU assets and lease liabilities due to lease modification
|
|
—
|
—
|
—
|
$0
|
$0
|
$723k
|
$649k
|
|
Stock-based compensation capitalized to inventory
|
|
—
|
—
|
$71k
|
$441k
|
$822k
|
$1.1m
|
$688k
|
|
Conversion of convertible notes, net into shares of common stock
|
|
—
|
—
|
—
|
—
|
$0
|
$0
|
$24k
|
|
Net cash provided by (used in) operating activities
|
|
($39.4m)
|
($89.1m)
|
($132.8m)
|
($120.1m)
|
($70.9m)
|
$10.3m
|
$55.8m
|
|
Purchase of investments
|
|
($152.0m)
|
($74.6m)
|
($198.0m)
|
($132.3m)
|
($27.3m)
|
($89.0m)
|
($97.4m)
|
|
Proceeds from maturities of investments
|
|
$24.5m
|
$85.9m
|
$155.6m
|
$140.3m
|
$153.0m
|
$19.9m
|
$74.4m
|
|
Net cash used in investing activities
|
|
($127.8m)
|
$37.9m
|
$48.5m
|
$7.7m
|
($107.2m)
|
($90.1m)
|
($24.0m)
|
|
Proceeds from issuance of common stock in private placement, net of issuance costs
|
|
$0
|
$10.0m
|
$0
|
$0
|
$202.2m
|
$0
|
$0
|
|
Proceeds from issuance of common stock in at-the-market offerings, net of issuance costs
|
|
$0
|
—
|
$0
|
$21.3m
|
$14.5m
|
$0
|
$0
|
|
Proceeds from issuance of common stock pursuant to equity plans
|
|
$0
|
$784k
|
$2.1m
|
$7.3m
|
$10.5m
|
$17.7m
|
$40.1m
|
|
Issuance of common stock in connection with settlement of Contingent Milestone and Indemnification Holdback liabilities
|
|
—
|
—
|
$0
|
$0
|
$5.2m
|
$0
|
$0
|
|
Net cash provided by financing activities
|
|
$127.2m
|
$181.3m
|
$73.5m
|
$109.1m
|
$336.6m
|
$17.7m
|
$40.1m
|
|
Effect of exchange rate on cash, cash equivalents and restricted cash
|
|
($27k)
|
$29k
|
($1k)
|
$12k
|
($133k)
|
($1.3m)
|
$3.2m
|
|
Net increase (decrease) in cash, cash equivalents and restricted cash
|
|
($40.0m)
|
$130.1m
|
($10.7m)
|
($3.3m)
|
$158.3m
|
($63.4m)
|
$75.2m
|
|
Cash, cash equivalents and restricted cash at beginning of period
|
|
$12.0m
|
$142.1m
|
$131.3m
|
$128.0m
|
$286.3m
|
$222.9m
|
$298.2m
|
|
Cash paid for interest
|
|
—
|
—
|
$0
|
$0
|
$6.8m
|
$12.7m
|
$12.7m
|
|
Cash paid for income taxes
|
|
$21k
|
$11k
|
$0
|
$0
|
$125k
|
$1.0m
|
$2.2m
|