|
Depreciation
|
|
$37k
|
$96k
|
$312k
|
$325k
|
$744k
|
$685k
|
$855k
|
|
Amortization of intangible assets
|
|
—
|
—
|
—
|
$0
|
$133k
|
$540k
|
$961k
|
|
Amortization/accretion of debt-related costs
|
|
—
|
—
|
$0
|
$309k
|
$385k
|
$482k
|
$593k
|
|
Net amortization/accretion on marketable securities
|
|
—
|
—
|
$0
|
($1.3m)
|
($3.2m)
|
($4.2m)
|
($5.5m)
|
|
Loss on debt extinguishment
|
|
$255k
|
$0
|
—
|
$0
|
$0
|
$1.9m
|
$0
|
|
Realized/unrealized loss (gain) on equity investments
|
|
—
|
—
|
—
|
$268k
|
($259k)
|
$591k
|
$0
|
|
Operating lease right-of-use asset obtained in exchange for operating lease liability
|
|
$163k
|
$726k
|
$741k
|
$0
|
$1.8m
|
$384k
|
$10.2m
|
|
Operating lease modification
|
|
—
|
—
|
—
|
$0
|
$0
|
$1.1m
|
$0
|
|
Net loss
|
|
($4.7m)
|
($26.8m)
|
($13.8m)
|
($62.1m)
|
($135.9m)
|
($115.6m)
|
($66.4m)
|
|
Stock-based compensation
|
|
$18k
|
$839k
|
$8.5m
|
$13.5m
|
$19.8m
|
$27.8m
|
$41.7m
|
|
Non-cash lease expense
|
|
—
|
$150k
|
$294k
|
$464k
|
$541k
|
$635k
|
$682k
|
|
Change in fair value of equity warrants issued by licensee
|
|
$76k
|
$0
|
$987k
|
$501k
|
($117k)
|
$201k
|
$0
|
|
Accounts receivable, net
|
|
—
|
—
|
—
|
$0
|
($16.6m)
|
($30.1m)
|
($38.3m)
|
|
Inventory
|
|
—
|
—
|
—
|
$0
|
($3.1m)
|
($2.0m)
|
($1.8m)
|
|
Other receivables
|
|
($32k)
|
$16k
|
($73k)
|
($3.5m)
|
$2.5m
|
($206k)
|
($754k)
|
|
Prepaid expenses
|
|
—
|
—
|
($2.0m)
|
($721k)
|
($2.9m)
|
($7.0m)
|
$1.7m
|
|
Other non-current assets
|
|
($6k)
|
($75k)
|
($2.3m)
|
($215k)
|
($718k)
|
$572k
|
($527k)
|
|
Accounts payable
|
|
$245k
|
$3.2m
|
$3.9m
|
$821k
|
$13.2m
|
$40.3m
|
$6.9m
|
|
Accrued payroll and benefits
|
|
$296k
|
$741k
|
$1.8m
|
$2.7m
|
$7.7m
|
$2.6m
|
$2.0m
|
|
Other accrued liabilities
|
|
—
|
—
|
—
|
—
|
$8.7m
|
$37.8m
|
$45.4m
|
|
Other long-term liabilities
|
|
—
|
$0
|
$115k
|
($67k)
|
$185k
|
($233k)
|
$0
|
|
Proceeds from sales and maturities of marketable securities
|
|
—
|
—
|
—
|
$5.3m
|
$174.8m
|
$73.0m
|
$361.8m
|
|
Purchases of marketable securities
|
|
—
|
—
|
$0
|
($149.4m)
|
($28.7m)
|
($262.6m)
|
($393.2m)
|
|
Intangible asset additions
|
|
—
|
—
|
—
|
$0
|
($4.0m)
|
($5.0m)
|
$0
|
|
Purchases of property and equipment
|
|
($175k)
|
($456k)
|
($586k)
|
($506k)
|
($1.5m)
|
($1.6m)
|
($9.9m)
|
|
Proceeds from issuance of pre-funded warrants, net of paid issuance costs
|
|
—
|
—
|
—
|
$0
|
$0
|
$9.4m
|
$0
|
|
Proceeds from exercise of stock options
|
|
—
|
$10k
|
$103k
|
$123k
|
$592k
|
$5.6m
|
$6.3m
|
|
Additions of property and equipment included within accounts payable and other accrued liabilities
|
|
$10k
|
$34k
|
$2k
|
$21k
|
$134k
|
$99k
|
$1.5m
|
|
Offering costs included within accounts payable
|
|
—
|
—
|
—
|
$0
|
$0
|
$21k
|
$0
|
|
Net cash used in operating activities
|
|
($3.7m)
|
($21.1m)
|
$3.7m
|
($49.0m)
|
($117.5m)
|
($83.0m)
|
($12.5m)
|
|
Purchases of long-term investments
|
|
—
|
—
|
—
|
$0
|
$0
|
($3.0m)
|
($870k)
|
|
Net cash (used in) provided by investing activities
|
|
($175k)
|
($456k)
|
($586k)
|
($144.6m)
|
$140.6m
|
($199.2m)
|
($42.1m)
|
|
Proceeds from long-term debt
|
|
—
|
—
|
—
|
$20.0m
|
$10.0m
|
$75.0m
|
$0
|
|
Payment of debt issuance costs
|
|
—
|
—
|
$0
|
($875k)
|
$0
|
($3.5m)
|
$0
|
|
Payments for debt extinguishment
|
|
—
|
—
|
—
|
$0
|
$0
|
($31.9m)
|
$0
|
|
Proceeds from issuance of common stock, net of paid issuance costs
|
|
—
|
—
|
—
|
$74.4m
|
$118.6m
|
$98.3m
|
$134.8m
|
|
Proceeds from sale of common stock under employee stock purchase plan
|
|
—
|
$0
|
$221k
|
$462k
|
$985k
|
$1.8m
|
$2.3m
|
|
Net cash provided by financing activities
|
|
$59.4m
|
$131.8m
|
$21k
|
$94.0m
|
$130.2m
|
$154.7m
|
$143.4m
|
|
Net increase (decrease) in cash, cash equivalents and restricted cash
|
|
$55.6m
|
$110.2m
|
$3.2m
|
($99.7m)
|
$153.3m
|
($127.6m)
|
$88.8m
|
|
Cash, cash equivalents and restricted cash at beginning of period
|
|
$58.0m
|
$168.1m
|
$171.3m
|
$71.7m
|
$224.9m
|
$97.4m
|
$186.2m
|
|
Interest expense paid in cash
|
|
—
|
—
|
$0
|
$1.7m
|
$2.9m
|
$7.7m
|
$8.3m
|