← IONIS PHARMACEUTICALS INC IONS
Market Price
$57.23
Market Cap
$9.23B
P/E Ratio
N/A
Revenue (FY 2025)
↑33.8% YoY
$943.71M
3-Yr CAGR: 17.1%
Net Income
↑16.0% YoY
-$381.39M
Net Margin: -40.4%
Free Cash Flow
↑41.4% YoY
-$320.03M
FCF Yield: -3.47%
EPS (Diluted)
↑21.7% YoY
$-2.38
Basic: $-2.38
Return on Equity
Efficiency
-78.0%
ROA: -12.8%
📊 Multi-Year Historical Performance & Trends
Financial Performance History
Revenue, Net Income & Free Cash Flow
Margins Trend (%)
Gross, Operating & Net Margins
Balance Sheet Strength
Cash, Debt & Equity
Cash Flow Generation
Operating Cash Flow vs CapEx vs FCF
📈 Year-over-Year (YoY) Growth History (IONS)
All monetary values in millions ($M)
⚠️ YoY Data Quality Alert
- FY 2017: Revenue YoY (+46.5%) is identical to Gross Profit YoY (+46.5%). Verify the underlying Revenue and Gross Profit values for FY 2017 and FY 2016.
| Fiscal Year | Revenue | Revenue YoY | Gross Profit | Net Income | Net Inc YoY | Diluted EPS | EPS YoY | Op. Cash Flow | Free Cash Flow | FCF YoY |
|---|---|---|---|---|---|---|---|---|---|---|
| FY 2016 | $346.6M | — | $86.7M | $-86.6M | — | — | — | $-112.1M | $-119.2M | — |
| FY 2017 | $507.7M | +46.5% | $126.9M | $-6.0M | +93.1% | $0.08 | — | $174.1M | $139.4M | +216.9% |
| FY 2018 | $599.7M | +18.1% | $554.9M | $273.7M | +4,685.3% | $2.07 | +2,487.5% | $602.9M | $589.3M | +322.8% |
| FY 2019 | $1,122.6M | +87.2% | $1,073.8M | $294.1M | +7.5% | $2.08 | +0.5% | $345.7M | $314.8M | -46.6% |
| FY 2020 | $729.3M | -35.0% | $684.3M | $-451.3M | -253.4% | $-3.23 | -255.3% | $35.9M | $0.8M | -99.8% |
| FY 2021 | $810.5M | +11.1% | $799.6M | $-28.6M | +93.7% | $-0.20 | +93.8% | $30.8M | $18.8M | +2,340.9% |
| FY 2022 | $587.4M | -27.5% | $573.3M | $-269.7M | -843.2% | $-1.90 | -850.0% | $-274.4M | $-290.1M | -1,639.4% |
| FY 2023 | $787.6M | +34.1% | $775.0M | $-366.3M | -35.8% | $-2.56 | -34.7% | $-307.5M | $-331.3M | -14.2% |
| FY 2024 | $705.1M | -10.5% | $688.1M | $-453.9M | -23.9% | $-3.04 | -18.8% | $-500.9M | $-546.2M | -64.9% |
| FY 2025 | $943.7M | +33.8% | $926.4M | $-381.4M | +16.0% | $-2.38 | +21.7% | $-268.6M | $-320.0M | +41.4% |
Valuation
Market Price
$57.23
Market Cap
$9.23B
Enterprise Value
$10.62B
P/E Ratio
N/A
P/B Ratio
19.34
FCF Yield
-3.47%
Dividend Yield
N/A
Shares Outstanding
Profitability & Margins
Gross Margin
98.17%
Operating Margin
-40.45%
Net Margin
-40.41%
Return on Equity (ROE)
-77.98%
Return on Assets (ROA)
-12.75%
Asset Turnover
0.32x
Revenue 3-Yr CAGR
17.12%
Financial Health & Liquidity
Current Ratio
28.19
Cash Ratio
3.51
Debt / Equity
3.599
Debt / Assets
0.589
Cash & Equivalents
$372.26M
Total Debt
$1.76B
Book Value / Share
$2.96
Cash Flow Efficiency
Operating Cash Flow
-$268.58M
Capital Expenditures (CapEx)
$51.44M
Free Cash Flow
-$320.03M
OCF / Revenue
-28.46%
FCF / Revenue
-33.91%
FCF 3-Yr CAGR
N/A
Per Share Metrics
EPS (Diluted)
$-2.38
EPS (Basic)
$-2.38
Dividends / Share
N/A
Book Value / Share
$2.96
EPS YoY Growth
21.71%
Balance Sheet (FY 2025)
Total Assets
$2.99B
Total Liabilities
$106.09M
Stockholders' Equity
$489.09M
Current Assets
$2.99B
Current Liabilities
$106.09M