← IONIS PHARMACEUTICALS INC
| Annual Trend | FY 2016 | FY 2017 | FY 2018 | FY 2019 | FY 2020 | FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||||||||
| Adjustments to reconcile net income to net cash provided by operating activities: | |||||||||||
| Net Income (Loss) Attributable to Parent | ($86.6m) | ($6.0m) | $273.7m | $294.1m | ($451.3m) | ($28.6m) | ($269.7m) | ($366.3m) | ($453.9m) | ($381.4m) | |
| Net Income (Loss) Available to Common Stockholders, Basic | — | $9.7m | $276.9m | $296.6m | ($451.5m) | — | — | — | — | — | |
| Net Income (Loss), Including Portion Attributable to Noncontrolling Interest | — | ($17.3m) | $215.0m | $303.3m | ($486.8m) | ($28.6m) | ($269.7m) | — | — | — | |
| Net Income (Loss) Attributable to Noncontrolling Interest | — | ($11.3m) | ($58.8m) | $9.1m | ($35.5m) | $0 | $0 | — | — | — | |
| Depreciation | $7.5m | $6.7m | $10.7m | $12.5m | $13.4m | $15.5m | $14.3m | $10.3m | $9.6m | $10.0m | |
| Amortization of Debt Issuance Costs | $1.2m | $1.6m | $1.8m | $1.9m | $2.6m | $5.0m | $5.4m | $6.3m | $6.7m | $6.9m | |
| Amortization of Debt Issuance Costs and Discounts | $25.1m | $32.5m | $35.2m | $39.3m | $38.7m | $4.9m | $5.4m | $6.3m | $6.7m | $6.9m | |
| Amortization of Intangible Assets | — | — | $1.8m | $1.9m | $2.1m | $2.4m | $2.4m | $2.6m | $2.3m | $2.4m | |
| Deferred Income Tax Expense (Benefit) | $0 | $0 | ($290.5m) | ($7.1m) | $313.3m | $0 | $0 | $0 | $0 | $0 | |
| Share-based Payment Arrangement, Noncash Expense | $72.1m | $86.0m | $131.3m | $146.6m | $230.1m | $120.7m | $100.3m | $105.8m | $130.2m | $133.9m | |
| Payment, Tax Withholding, Share-based Payment Arrangement | — | — | — | $19.2m | $13.4m | $16.7m | $11.0m | $0 | $0 | — | |
| Share-based Payment Arrangement, Expense | $72.1m | $86.0m | $131.3m | $146.6m | $230.1m | $120.7m | $100.3m | $105.8m | $130.2m | $133.9m | |
| Impairment of Intangible Assets, Finite-lived | — | — | — | — | $1.9m | $2.7m | $2.0m | $1.7m | $3.0m | $986k | |
| Share-based Payment Arrangement, Expensed and Capitalized, Amount | — | — | — | — | — | — | — | — | $131.0m | $135.7m | |
| Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property | $2.3m | $3.3m | $1.0m | $2.0m | $0 | $0 | ($531k) | ($16.6m) | ($7.4m) | $4.0m | |
| Gain (Loss) on Disposition of Assets | — | — | — | — | — | — | $149.6m | ($161k) | ($12k) | — | |
| Gain (Loss) on Extinguishment of Debt | ($4.0m) | $0 | $0 | ($21.9m) | $0 | ($8.6m) | $0 | $13.4m | $0 | $0 | |
| Income Tax Expense (Benefit) | $2.9m | ($6.0m) | ($291.1m) | $43.5m | $316.7m | ($551k) | $11.7m | $32.3m | ($6.2m) | $1.8m | |
| Operating Lease, Expense | — | — | — | $3.6m | $3.7m | $3.4m | $8.3m | $23.1m | $23.2m | $26.0m | |
| Other Nonoperating Income (Expense) | — | — | ($182k) | ($686k) | ($62k) | ($1.1m) | ($7.3m) | $14.3m | $1.3m | ($15.4m) | |
| Changes in operating assets and liabilities: | |||||||||||
| Additional Financial Items | |||||||||||
| Increase (Decrease) in Inventories | $590k | $2.5m | ($1.4m) | $5.4m | $1.3m | $2.8m | ($2.8m) | $6.4m | $5.1m | $13.7m | |
| Increase (Decrease) in Accounts Payable | ($10.7m) | $1.8m | ($655k) | ($16.3m) | ($2.8m) | ($6.0m) | $1.1m | $8.1m | $16.0m | ($15.4m) | |
| Gain (Loss) on Investments | — | — | — | ($192k) | $16.5m | $10.1m | ($7.3m) | ($1.9m) | ($2.9m) | $10.2m | |
| General and Administrative Expense | $48.6m | — | — | — | — | — | — | — | — | — | |
| Induced Conversion of Convertible Debt Expense | — | — | — | — | — | — | — | — | — | $16.3m | |
| Inventory Write-down | $0 | $0 | $0 | — | — | — | — | — | — | — | |
| Operating Expenses | $392.9m | $483.1m | $661.0m | — | — | — | — | — | — | — | |
| Realized Investment Gains (Losses) | — | — | — | — | — | $1.1m | ($224k) | ($1.6m) | ($2.9m) | $9.3m | |
| Net Cash Provided by (Used in) Operating Activities | ($112.1m) | $174.1m | $602.9m | $345.7m | $35.9m | $30.8m | ($274.4m) | ($307.5m) | ($500.9m) | ($268.6m) | |
| Cash flows from investing activities: | |||||||||||
| Payments to Acquire Property, Plant, and Equipment | $7.1m | $34.8m | $13.6m | $30.9m | $35.1m | $12.0m | $15.7m | $23.8m | $45.3m | $51.4m | |
| Net Cash Provided by (Used in) Investing Activities | $56.6m | ($358.3m) | ($929.6m) | ($41.3m) | $274.5m | $194.9m | ($262.6m) | ($214.1m) | ($134.0m) | ($277.8m) | |
| Cash flows from financing activities: | |||||||||||
| Proceeds from Issuance of Common Stock | $13.4m | $71.7m | $27.9m | $119.7m | $0 | $11.6m | $6.4m | $49.4m | $489.1m | $0 | |
| Payments for Repurchase of Common Stock | — | — | — | $34.4m | $90.5m | $0 | $0 | — | — | — | |
| Net Cash Provided by (Used in) Financing Activities | $11.4m | $229.1m | $475.9m | $100.0m | ($596.6m) | $245.9m | ($55.3m) | $644.1m | $478.1m | $675.8m | |
| Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect | ($44.1m) | $44.9m | $149.2m | $404.5m | ($285.6m) | $471.5m | ($592.7m) | $122.8m | ($157.2m) | $130.2m | |
| Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents | — | — | — | $683.3m | $397.7m | $869.2m | $276.5m | $399.3m | $242.1m | $372.3m | |
| Supplemental disclosure of cash flow information: | |||||||||||
| Interest Paid, Excluding Capitalized Interest, Operating Activities | $7.3m | $8.0m | $9.6m | $9.9m | $6.2m | $4.8m | $2.9m | $6.5m | $10.9m | $10.8m | |
| Income Taxes Paid, Net | — | $0 | $0 | $9.0m | $25.9m | $38k | $5.0m | $48.3m | ($5.6m) | ($639k) |
Values abbreviated: b = billions, m = millions, k = thousands. Per share data in USD.